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| First Round Draft Pick History |
| 1 | 6 | 6 | 2021 | 28 Man Draft | P | Kenley | Jansen | MLB |
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| 1 | 6 | 6 | 2021 | Annual Draft | P | Tarik | Skubal | MLB |
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| Complete Draft History |
| 1 | 6 | 6 | 2021 | Annual Draft | P | Tarik | Skubal | MLB |
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| 1 | 6 | 6 | 2021 | 28 Man Draft | P | Kenley | Jansen | MLB |
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| 2 | 6 | 30 | 2021 | 28 Man Draft | 1B | Daniel | Vogelbach | MLB |
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| 2 | 6 | 30 | 2021 | Annual Draft | C | Sam | Huff | MLB |
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| 3 | 6 | 54 | 2021 | 28 Man Draft | P | Duane | Underwood | MLB |
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| 3 | 6 | 54 | 2021 | Annual Draft | OF | Leody | Taveras | MLB |
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| 4 | 6 | 78 | 2021 | Annual Draft | 3B | Isaac | Paredes | MLB |
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| 5 | 6 | 102 | 2021 | Annual Draft | 3B+ | Phillip | Evans | MLB |
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| 6 | 6 | 126 | 2021 | Annual Draft | P | Braxton | Garrett | MLB |
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| 7 | 6 | 150 | 2021 | Annual Draft | OF | Eli | White | MLB |
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| 8 | 6 | 174 | 2021 | Annual Draft | P | Tucker | Davidson | MLB |
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| 9 | 6 | 198 | 2021 | Annual Draft | P | John | King | MLB |
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| 10 | 6 | 222 | 2021 | Annual Draft | P | Beau | Burrows | MLB |
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